For some, and I’d venture that with poets it is more than ‘one-fourth’, lithium does involve losing these times of heightened artistic facility and productivity. Of course many poets have no affective illness, and many who do find lithium works for them, but if Shelley had lived under a medical absolutism that insisted all manic-depressives should be on lithium, he may never have said that ‘poets are the unacknowledged legislators of the world’.
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